Yes, it works with Mach4. Note that there are some compatibility issues with the current version of Mach4, and an older version is recommended at this time. Please check these instructions which contain a link to the version that is recommended: https://www.cnc4pc.com/blog/post/initial-step-by-step-wiring-and-testing-of-a-c94-with-mach4 If you have any issues with this, please do not hesitate in contacting and we will give you a hand with this.